Filtration Systems
Description
Fully Automated Ultrafiltration , TFF ,MF , NF ,DF System
Flexible Configuration
Multiple Control Modes
Multiple Control Platforms
Inline Integrity Test
Water Flux Test
Custom Design Available
Fully automatic ultrafiltration TFF systems are designed for downstream separation and purification processes of biopharmaceuticals.
The systems can be used for the concentration of large molecule solution and buffer exchange or diafiltration in Ultrafiltration or clarification of unwanted large particles and cells in microfiltration. Our systems can be built for either cassette or hollow fiber membranes.
The systems are suitable for biopharmaceutical production at different scales and development stages, covering lab, pilot, to production scales.
The system can be customized according to user requirements and GAMP project execution for delivery is available for customers in the cGMP regulated industry.
- The Fitration type can be selected flexibly according to different processes, which can adapt to the different kind of hollow fiber cartridge and flat membrane cassette, to realize ultrafiltration, concentration, buffer exchange or clarification microfiltration process.
- The Control strategy includes various control modes such as constant TMP, constant Fr, constant P and fixed pump speed, covering the need for most ultrafiltration processes. Other special control strategy can be customized.
- The system includes an inline integrity test module, which can complete the integrity test without disassembling the membrane cassettes/ cartridge, based on brands, models and membrane areas. Test result can be saved in the batch report.
- The system can perform inline water flux test function, and save the result in the batch report.
- Ultrafiltration software can be based on different platform, such as DCS (Delta V or PCS 7) or PLC control (WinCC or Lab Windows).All control platforms meet the requirements of FDA 21 CFR Part 11 electronic signature, electronic record and audit trail requirements.
- The system can be fuly customized according to the plant layout and the process train to meet the customers need.
Single-Use Ultrafiltration System
- Four specifications are optional: 0.5m2, 5m2, 10m2, 20m2
- Circulating pump: peristaltic pump and disposable PP diaphragm pump head are optional
- Clamping holder PP material
- Disposable consumables, sterilization by Radiation
- Supporting integration with mixer
TFF Cassette Holder
- Specificatins: 0.1-0.5m, 0.5-m-5m, 5-20m, 20-40m, 30-60m, 40-80m and other holders covering the needfrom R&D to commerical production. Through combining the holders, 200m of cassette membrane can be achieved.
- Compatible with most membrane cassettes such as those from PALL, Sartorius, Millipore, TangenX, etc.
- Surface roughness, Ra<0.4um.
- The holders can be manual or hydraulic driven.
